Linked Life Data

6830624

Source:http://linkedlifedata.com/resource/pubmed/id/6830624

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1983-4-15
pubmed:abstractText
Melphalan and vincristine together with their radiolabelled derivatives were entrapped in small unilamellar liposomes of varying cholesterol content and phospholipid composition. After intravenous injection of drug-containing egg phosphatidylcholine liposomes into mice, drug clearance rates from the blood were reduced with increasing cholesterol content. Circulating drugs were partially associated with the carrier and partly free, mostly bound to plasma proteins. The ratio of drug associated with liposomes to that circulating as free was dependent on the type of liposomes used and highest when these were cholesterol-rich. Drug clearance rates were reduced and entrapped: free drug ratios increased further when egg phosphatidylcholine in cholesterol-rich liposomes was replaced by sphingomyelin. Drug-containing cholesterol-rich liposomes injected intraperitoneally were found capable of entering the periphery intact and quantitatively to assume clearance rates similar to those observed after intravenous treatment. Such manipulations in liposomal lipid composition can alter pharmacokinetics in ways that could provide optimal conditions for drug distribution into tumours and a therapeutic effect.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0006-2952
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
32
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
609-15
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1983
pubmed:articleTitle
The effect of lipid composition of small unilamellar liposomes containing melphalan and vincristine on drug clearance after injection into mice.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.