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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
1983-4-15
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pubmed:abstractText |
The aim of this study was to determine if a three-day treatment of lower urinary tract infection (UTI) is effective. 215 women with symptoms of lower UTI, seen in general practice, were randomly allocated to a double-blind study and given either amoxycillin 1000 mg twice a day for three days or trimethoprim 90 mg/sulphadiazine 410 mg (co-trimazine) 2 tablets initially, then one tablet twice daily for three days. 157 women (73%) had significant bacteriuria. Therapeutic efficacy was evaluated in 146 patients. One week after treatment had started, 88% of the women in the amoxycillin group and 100% in the co-trimazine group were cured (p less than 0.01). After a follow-up period of four weeks, the cumulative relapse frequencies were 19% and 9% respectively. Adverse reactions were mild in most cases. Two patients, both on co-trimazine, had to discontinue treatment because of nausea and vomiting. Vulvovaginal irritation was more often reported by women treated with amoxycillin (n = 8) than by those treated with co-trimazine (n = 1) (p less than 0.05). It is concluded that a three-day course of amoxycillin or co-trimazine in lower UTI is safe, causes few adverse reactions, is simple to administer and comfortable for the patient. Co-trimazine seems to be more effective than amoxycillin.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Amoxicillin,
http://linkedlifedata.com/resource/pubmed/chemical/Anti-Infective Agents, Urinary,
http://linkedlifedata.com/resource/pubmed/chemical/Drug Combinations,
http://linkedlifedata.com/resource/pubmed/chemical/Sulfadiazine,
http://linkedlifedata.com/resource/pubmed/chemical/Trimethoprim,
http://linkedlifedata.com/resource/pubmed/chemical/sulfadiazine, trimethoprim drug...
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pubmed:status |
MEDLINE
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pubmed:issn |
0001-6101
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
213
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
55-60
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pubmed:dateRevised |
2010-11-10
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pubmed:meshHeading |
pubmed-meshheading:6829321-Adolescent,
pubmed-meshheading:6829321-Adult,
pubmed-meshheading:6829321-Aged,
pubmed-meshheading:6829321-Amoxicillin,
pubmed-meshheading:6829321-Anti-Infective Agents, Urinary,
pubmed-meshheading:6829321-Bacteriuria,
pubmed-meshheading:6829321-Double-Blind Method,
pubmed-meshheading:6829321-Drug Combinations,
pubmed-meshheading:6829321-Female,
pubmed-meshheading:6829321-Follow-Up Studies,
pubmed-meshheading:6829321-Humans,
pubmed-meshheading:6829321-Middle Aged,
pubmed-meshheading:6829321-Random Allocation,
pubmed-meshheading:6829321-Sulfadiazine,
pubmed-meshheading:6829321-Trimethoprim,
pubmed-meshheading:6829321-Urinary Tract Infections
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pubmed:year |
1983
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pubmed:articleTitle |
Three-day treatment of acute lower urinary tract infections in women. A double-blind study with amoxycillin and co-trimazine.
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Comparative Study,
Randomized Controlled Trial
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