Linked Life Data

6829274

Source:http://linkedlifedata.com/resource/pubmed/id/6829274

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1983-4-21
pubmed:abstractText
Maternal administration of a single dose of cyclophosphamide (20 mg/kg) after the neural tube closure (on day 12) resulted in exencephaly and cranioschisis in 100% of rat fetuses at term. Extensive hemorrhages and edema were regularly associated with these defects. Alizarin-red stained skeletal preparations revealed absence of skull vault, premature closure of basicranial synchondroses, exaggeration of the craniovertebral angle, and agencies and hypoplasia of the vertebrae, ribs and sternum. It is suggested that failure of the neural tube to close is not the primary cause of axial skeletal malformations and even after closure, the axial skeletal anlagen remains susceptible to teratogenic insult.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0001-6470
pubmed:author
pubmed:issnType
Print
pubmed:volume
54
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
104-12
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1983
pubmed:articleTitle
Axial skeletal malformations associated with cranioschisis aperta and exencephaly. The result of experimental intervention after the neural tube closure in rats.
pubmed:publicationType
Journal Article