Linked Life Data

6828648

Source:http://linkedlifedata.com/resource/pubmed/id/6828648

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1983-4-15
pubmed:abstractText
The effect of vagal stimulation induced by 2-deoxy-D-glucose (2DG) on gastric acid and pancreatic bicarbonate output, and portal gastrin and secretin concentrations, was assessed in conscious miniature pigs. Electrical vagal stimulation has previously been shown to induce profuse pancreatic water and bicarbonate secretion in anaesthetized pigs. Pigs in this study were surgically prepared with gastric and pancreatic fistulas and indwelling jugular and portal catheters. An intravenous bolus of 2DG (100 mg/kg body weight) caused a significant increase in both gastric acid and pancreatic bicarbonate output although the latter was about 50% of the reported response to electrical vagal stimulation. Portal gastrin concentration rose significantly after 2DG, but the portal secretin concentration did not change. The presence of secretin in the small intestine was confirmed by intrajejunal HCl infusion. Failure of portal secretin concentration to rise after 2DG infusion rules against a role for this hormone in the pancreatic response.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0144-8757
pubmed:author
pubmed:issnType
Print
pubmed:volume
68
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
69-75
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1983
pubmed:articleTitle
Simultaneous pancreatic, gastric and hormonal responses to 2-deoxyglucose in the conscious pig.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.