|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
3
|
|
pubmed:dateCreated |
1983-4-15
|
|
pubmed:abstractText |
Uteroglobin binds progesterone with high affinity. A few substituted diphenyl ketones were observed to inhibit uteroglobin-progesterone binding in a dose-dependent manner. 4,4'-Dimethoxy-2-hydroxy benzophenone had relatively higher affinity for uteroglobin. The structure-activity relationship amongst the substituted diphenyl ketones indicated considerable sensitivity towards minor structural modifications. These observations offer a tool to investigate nonsteroidal compounds in relation to progesterone related functions of uteroglobin in pregnancy.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Mar
|
|
pubmed:issn |
0022-4731
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
18
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
303-8
|
|
pubmed:dateRevised |
2006-11-15
|
|
pubmed:meshHeading |
pubmed-meshheading:6827835-Animals,
pubmed-meshheading:6827835-Benzophenones,
pubmed-meshheading:6827835-Binding Sites,
pubmed-meshheading:6827835-Dithioerythritol,
pubmed-meshheading:6827835-Female,
pubmed-meshheading:6827835-Glycoproteins,
pubmed-meshheading:6827835-Ketones,
pubmed-meshheading:6827835-Progesterone,
pubmed-meshheading:6827835-Protein Binding,
pubmed-meshheading:6827835-Rabbits,
pubmed-meshheading:6827835-Structure-Activity Relationship,
pubmed-meshheading:6827835-Tritium,
pubmed-meshheading:6827835-Uteroglobin
|
|
pubmed:year |
1983
|
|
pubmed:articleTitle |
Specific interaction of some non-steroidal compounds with the progesterone binding site of uteroglobin.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
