Linked Life Data

6827094

Source:http://linkedlifedata.com/resource/pubmed/id/6827094

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1983-4-7
pubmed:abstractText
Covalent complexes of various sizes were made by coupling the photosensitive hapten, NAP (4-azido-2-nitrophenyl), to rabbit IgG and reacting the conjugates with rabbit anti-NAP antibodies. The resultant oligomers were stable, being eluted as the same discrete peaks after chromatography on gels both before and after injection into mice. Tests of their biological properties showed they fixed guinea pig complement in vitro in a size-dependent manner. Normal mice and mice with chronic endogenous circulating complexes cleared the oligomers according to size in a manner best described by a two-component exponential curve. There was no difference in the clearance rates between the two groups of mice. The advantages of these model complexes for examining the effect of circulating complexes on the mononuclear phagocyte system are discussed.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0022-1759
pubmed:author
pubmed:issnType
Print
pubmed:day
28
pubmed:volume
56
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
149-58
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
1983
pubmed:articleTitle
Preparation of covalent IgG complexes of defined size and their clearance from the circulation of mice.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't