Statements in which the resource exists.
SubjectPredicateObjectContext
pubmed-article:6826227rdf:typepubmed:Citationlld:pubmed
pubmed-article:6826227lifeskim:mentionsumls-concept:C0035820lld:lifeskim
pubmed-article:6826227lifeskim:mentionsumls-concept:C0002006lld:lifeskim
pubmed-article:6826227lifeskim:mentionsumls-concept:C0870883lld:lifeskim
pubmed-article:6826227lifeskim:mentionsumls-concept:C0205460lld:lifeskim
pubmed-article:6826227pubmed:issue2 Pt 2lld:pubmed
pubmed-article:6826227pubmed:dateCreated1983-4-21lld:pubmed
pubmed-article:6826227pubmed:abstractTextFollowing the incubation of aldosterone with microsomes from liver of adrenalectomized male rates, a previously unidentified polar neutral metabolite of aldosterone, designated "peak A" material, was isolated and purified using high pressure liquid chromatography. This peak A material, which contains a reduced hydroxylated metabolite of aldosterone, was shown to possess 2% to 3.5% of the mineralocorticoid activity relative to aldosterone. When bovine adrenal glomerulosa cells were incubated with peak A material (3 and 10 micrograms/ml), the binding of 125I-angiotensin II was inhibited by 20% and 36%, respectively. The mineralocorticoid activity of the six possible ring A reduced metabolites was tested. The 5 alpha-reduced metabolites were more potent than the 5 beta-, and the 3 alpha- were more potent than the 3 beta-reduced metabolites. The renal and extrarenal transformations of aldosterone to the polar and nonpolar (reduced) metabolites and their possible role in the accepted mechanism of action of aldosterone is discussed.lld:pubmed
pubmed-article:6826227pubmed:granthttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:6826227pubmed:granthttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:6826227pubmed:languageenglld:pubmed
pubmed-article:6826227pubmed:journalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:6826227pubmed:citationSubsetIMlld:pubmed
pubmed-article:6826227pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:6826227pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:6826227pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:6826227pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:6826227pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:6826227pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:6826227pubmed:statusMEDLINElld:pubmed
pubmed-article:6826227pubmed:issn0194-911Xlld:pubmed
pubmed-article:6826227pubmed:authorpubmed-author:GoodfriendT...lld:pubmed
pubmed-article:6826227pubmed:authorpubmed-author:McDermottMMlld:pubmed
pubmed-article:6826227pubmed:authorpubmed-author:KenyonC JCJlld:pubmed
pubmed-article:6826227pubmed:authorpubmed-author:MorrisD JDJlld:pubmed
pubmed-article:6826227pubmed:authorpubmed-author:LatifS ASAlld:pubmed
pubmed-article:6826227pubmed:issnTypePrintlld:pubmed
pubmed-article:6826227pubmed:volume5lld:pubmed
pubmed-article:6826227pubmed:ownerNLMlld:pubmed
pubmed-article:6826227pubmed:authorsCompleteYlld:pubmed
pubmed-article:6826227pubmed:paginationI35-40lld:pubmed
pubmed-article:6826227pubmed:dateRevised2007-11-14lld:pubmed
pubmed-article:6826227pubmed:meshHeadingpubmed-meshheading:6826227-...lld:pubmed
pubmed-article:6826227pubmed:meshHeadingpubmed-meshheading:6826227-...lld:pubmed
pubmed-article:6826227pubmed:meshHeadingpubmed-meshheading:6826227-...lld:pubmed
pubmed-article:6826227pubmed:meshHeadingpubmed-meshheading:6826227-...lld:pubmed
pubmed-article:6826227pubmed:meshHeadingpubmed-meshheading:6826227-...lld:pubmed
pubmed-article:6826227pubmed:meshHeadingpubmed-meshheading:6826227-...lld:pubmed
pubmed-article:6826227pubmed:meshHeadingpubmed-meshheading:6826227-...lld:pubmed
pubmed-article:6826227pubmed:meshHeadingpubmed-meshheading:6826227-...lld:pubmed
pubmed-article:6826227pubmed:meshHeadingpubmed-meshheading:6826227-...lld:pubmed
pubmed-article:6826227pubmed:meshHeadingpubmed-meshheading:6826227-...lld:pubmed
pubmed-article:6826227pubmed:meshHeadingpubmed-meshheading:6826227-...lld:pubmed
pubmed-article:6826227pubmed:meshHeadingpubmed-meshheading:6826227-...lld:pubmed
pubmed-article:6826227pubmed:meshHeadingpubmed-meshheading:6826227-...lld:pubmed
pubmed-article:6826227pubmed:meshHeadingpubmed-meshheading:6826227-...lld:pubmed
pubmed-article:6826227pubmed:articleTitleThe possible biological role of aldosterone metabolites.lld:pubmed
pubmed-article:6826227pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:6826227pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed