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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2 Pt 2
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pubmed:dateCreated |
1983-4-21
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pubmed:abstractText |
Following the incubation of aldosterone with microsomes from liver of adrenalectomized male rates, a previously unidentified polar neutral metabolite of aldosterone, designated "peak A" material, was isolated and purified using high pressure liquid chromatography. This peak A material, which contains a reduced hydroxylated metabolite of aldosterone, was shown to possess 2% to 3.5% of the mineralocorticoid activity relative to aldosterone. When bovine adrenal glomerulosa cells were incubated with peak A material (3 and 10 micrograms/ml), the binding of 125I-angiotensin II was inhibited by 20% and 36%, respectively. The mineralocorticoid activity of the six possible ring A reduced metabolites was tested. The 5 alpha-reduced metabolites were more potent than the 5 beta-, and the 3 alpha- were more potent than the 3 beta-reduced metabolites. The renal and extrarenal transformations of aldosterone to the polar and nonpolar (reduced) metabolites and their possible role in the accepted mechanism of action of aldosterone is discussed.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Aldosterone,
http://linkedlifedata.com/resource/pubmed/chemical/Angiotensin II,
http://linkedlifedata.com/resource/pubmed/chemical/Mineralocorticoids,
http://linkedlifedata.com/resource/pubmed/chemical/Potassium,
http://linkedlifedata.com/resource/pubmed/chemical/Sodium,
http://linkedlifedata.com/resource/pubmed/chemical/tetrahydroaldosterone
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pubmed:status |
MEDLINE
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pubmed:issn |
0194-911X
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
5
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
I35-40
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:6826227-Adrenal Glands,
pubmed-meshheading:6826227-Adrenalectomy,
pubmed-meshheading:6826227-Aldosterone,
pubmed-meshheading:6826227-Angiotensin II,
pubmed-meshheading:6826227-Animals,
pubmed-meshheading:6826227-Chromatography, High Pressure Liquid,
pubmed-meshheading:6826227-Male,
pubmed-meshheading:6826227-Microsomes, Liver,
pubmed-meshheading:6826227-Mineralocorticoids,
pubmed-meshheading:6826227-Natriuresis,
pubmed-meshheading:6826227-Potassium,
pubmed-meshheading:6826227-Rats,
pubmed-meshheading:6826227-Rats, Inbred Strains,
pubmed-meshheading:6826227-Sodium
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pubmed:articleTitle |
The possible biological role of aldosterone metabolites.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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