Linked Life Data

6825173

Source:http://linkedlifedata.com/resource/pubmed/id/6825173

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1983-4-15
pubmed:abstractText
Clones containing nine different larval and adult globin genes have been isolated from two genomic libraries of Xenopus laevis. They encompass three distinct DNA regions: a 70 kb region containing five genes in the order 5'-alpha Lla-alpha Llb-alpha Al-beta Al-beta Lla-3', all with the same transcriptional polarity; a 40 kb region with three genes, 5'-alpha Llla-alpha Lllb-alpha All-3', again with the same polarity; and a 10 kb segment comprising the beta Llla gene only. The beta All gene has not been found in our libraries. Genetic analysis has revealed two more beta L genes (beta Lllb, beta Lllb). Globin-like sequences have also been isolated, but have not been further characterized. The X. laevis globin gene family thus consists of 12 genes arranged in two clusters, each containing larval and adult alpha and beta genes in a unique, "symmetrical" arrangement. Electron microscopic analysis has revealed that Xenopus globin genes also comprise three exons and two introns, but differ from the globin genes of higher vertebrates in that the introns are much larger.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0092-8674
pubmed:author
pubmed:issnType
Print
pubmed:volume
32
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
45-53
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed:year
1983
pubmed:articleTitle
The Xenopus laevis globin gene family: chromosomal arrangement and gene structure.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't