Linked Life Data

6824372

Source:http://linkedlifedata.com/resource/pubmed/id/6824372

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1983-3-11
pubmed:abstractText
In a prospective study 376 carotid artery plaques (275 symptomatic, 101 asymptomatic) were obtained from endarterectomies (184 unilateral and 96 bilateral) in 280 patients. The gross morphologic features of each plaque were noted at surgery and, together with the patient's clinical history, stored in computer memory. These data were analyzed in order to investigate the relationship of gross morphologic plaque characteristics with both the presence of cerebral symptoms and the degree of stenosis associated with the plaque. Ulceration was the most frequently observed of the five major gross plaque morphologic characteristics (46.0% of all plaques), but only intramural hemorrhage (30.6% of all plaques) was significantly more common in all symptomatic compared with all asymptomatic plaques (p less than 0.02). Hemorrhage was also the only gross characteristic significantly more common in focal symptomatic plaques when compared with either asymptomatic plaques (p less than 0.05) or nonfocal symptomatic plaques (p less than 0.01). When all the plaques were divided into three broad degrees of stenosis groups (0-39%, 40-69%, 70-99%) on the basis of angiographic data, only hemorrhage showed a significant correlation in incidence with increased degree of plaque stenosis, both when all plaques were considered (p less than 0.001) and when only symptomatic plaques were examined (p less than 0.001). The results indicate that intramural hemorrhage is the only carotid plaque gross morphologic characteristic significantly more frequent in symptomatic compared with asymptomatic plaques and the only characteristic significantly correlated with increased plaque size. These findings indicate that factors other than plaque ulceration and intraluminal thrombus play an important role in carotid plaque related cerebral symptoms. The data also raise questions concerning the unequivocal value of anticoagulant therapy in carotid artery disease, especially in highly stenotic lesions.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/6824372-13180055, http://linkedlifedata.com/resource/pubmed/commentcorrection/6824372-13908419, http://linkedlifedata.com/resource/pubmed/commentcorrection/6824372-13958005, http://linkedlifedata.com/resource/pubmed/commentcorrection/6824372-14048196, http://linkedlifedata.com/resource/pubmed/commentcorrection/6824372-14116853, http://linkedlifedata.com/resource/pubmed/commentcorrection/6824372-14810286, http://linkedlifedata.com/resource/pubmed/commentcorrection/6824372-324035, http://linkedlifedata.com/resource/pubmed/commentcorrection/6824372-324036, http://linkedlifedata.com/resource/pubmed/commentcorrection/6824372-462508, http://linkedlifedata.com/resource/pubmed/commentcorrection/6824372-5381060, http://linkedlifedata.com/resource/pubmed/commentcorrection/6824372-5489295, http://linkedlifedata.com/resource/pubmed/commentcorrection/6824372-5675281, http://linkedlifedata.com/resource/pubmed/commentcorrection/6824372-5921300, http://linkedlifedata.com/resource/pubmed/commentcorrection/6824372-6250417, http://linkedlifedata.com/resource/pubmed/commentcorrection/6824372-6894688, http://linkedlifedata.com/resource/pubmed/commentcorrection/6824372-7212183, http://linkedlifedata.com/resource/pubmed/commentcorrection/6824372-921536
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0003-4932
pubmed:author
pubmed:issnType
Print
pubmed:volume
197
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
195-203
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1983
pubmed:articleTitle
The importance of hemorrhage in the relationship between gross morphologic characteristics and cerebral symptoms in 376 carotid artery plaques.
pubmed:publicationType
Journal Article