Linked Life Data

6824078

Source:http://linkedlifedata.com/resource/pubmed/id/6824078

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1983-3-17
pubmed:abstractText
The C57BL/6J mouse is an inbred strain with selective hypertaurinuria. C3H/HeJ mice (control) and C57BL/6J mice have comparable values for plasma taurine and renal creatinine clearance but significantly different fractional taurine excretion: C3H mice, 0.15 +/- 0.03; C57BL mice, 0.44 +/- 0.08 (P less than 0.01). C57BL mice fed control diet have significantly higher renal cortex taurine (11.5 +/- 0.4 mumol/g wet wt, mean +/- SE) relative to C3H mice (10.5 +/- 0.5 mumol/g, P less than 0.05); the difference is magnified when mice are fed low protein or low sulfur amino acid diet and experience renal adaptation with enhanced taurine transport at the luminal membrane (P less than 0.01). Taurine transport by purified brush border membrane vesicles is similar in the two strains fed control diet. On the other hand, renal cortex slices show the following differences: 1) net uptake of taurine at 0.11 mM is lower in C57BL slices at initial rates and at steady state; 2) the difference in uptake between strains is magnified in the presence of phlorizin, an inhibitor of taurine efflux; 3) efflux of taurine from preloaded slices is less per unit time in C57BL mice; and 4) uptake differences are specific for taurine. These findings are not accountable to differences in taurine oxidation, slice weight, or water spaces. They indicate that hypertaurinuria in the C57BL/6J strain is a function of decreased basolateral membrane permeability to taurine at physiologic concentrations.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0002-9513
pubmed:author
pubmed:issnType
Print
pubmed:volume
244
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
F150-5
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1983
pubmed:articleTitle
Hypertaurinuria in the C57BL/6J mouse: altered transport at the renal basolateral membrane.
pubmed:publicationType
Journal Article, In Vitro, Research Support, Non-U.S. Gov't