Linked Life Data

6823331

Source:http://linkedlifedata.com/resource/pubmed/id/6823331

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5900
pubmed:dateCreated
1983-3-24
pubmed:abstractText
Although intracellular pH (pHi) has important effects on both the mechanical and electrical properties of cardiac muscle, the control of pHi in the heart is still poorly understood. One important determinant of pHi appears to be the transmembrane Na+ gradient. It has therefore been suggested that Na+-H+ exchange assists in the control of pHi in heart as has been proposed for other excitable cells. However, pHi and the intracellular Ca2+ concentration ([Ca2+]i) are interdependent in a variety of tissues and it has been shown recently that pHi can affect [Ca2+]i in cardiac muscle. As [Ca2+]i in cardiac muscle is also strongly influenced by the transmembrane Na+ gradient it is possible that the apparent Na+-dependence of pHi is secondary to changes in [Ca2+]i. Previous work in cardiac muscle has not been able to separate the effects of Na+-H+ exchange and [Ca2+]i on pHi (refs 4,5). Here we demonstrate in cardiac muscle that an increase in [Ca2+]i produces an intracellular acidification which cannot be ascribed to Na+-H+ exchange.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0028-0836
pubmed:author
pubmed:issnType
Print
pubmed:day
10
pubmed:volume
301
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
522-4
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1983
pubmed:articleTitle
Ca2+ ions can affect intracellular pH in mammalian cardiac muscle.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't