Linked Life Data

682127

Source:http://linkedlifedata.com/resource/pubmed/id/682127

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1978-10-27
pubmed:abstractText
Hydrolysis and metabolism of N-benzoyl-L-tyrosyl-p-aminobenzoic acid (Bz-ty-PABA), a synthetic peptide used for the assessment of exocrine pancreatic function, were studied in normal and pancreatic duct-ligated rats and guinea pigs. Bz-ty-PABA was specifically cleaved by chymotrypsin to N-benzoyl-L-tyrosine and p-aminobenzoic acid (PABA) in mucosal homogenates of the intestine. Both of the resultant products were rapidly absorbed and excreted in the urine after oral administration of two kinds of radioactive Bz-ty-PABA (Bz[14C] and PABA[14C]) to animals. The absorption rate was correlated to the intestinal chymotrypsin activity obtained from in vitro studies. Benzoic acid and p-acetaminobenzoic acid were predominant in the urine after dosages of Bz-ty-PABA with Bz[14C] and PABA[14C], respectively, in both species. Additionally, a small amount of unchanged form of Bz-ty-PABA was excreted in the urine and bile without being cleaved by chymotrypsin. These results and the study using intravenous injections suggest that the absorption of this intact peptide may be almost 10% of the dose.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0022-3565
pubmed:author
pubmed:issnType
Print
pubmed:volume
206
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
468-74
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1978
pubmed:articleTitle
Hydrolysis and metabolism of N-benzoyl-L-tyrosyl-p-aminobenzoic acid in normal and pancreatic duct-ligated animals.
pubmed:publicationType
Journal Article