Linked Life Data

6820417

Source:http://linkedlifedata.com/resource/pubmed/id/6820417

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1983-6-10
pubmed:abstractText
Monospecific antibodies against human phenylalanine hydroxylase were prepared. Liver extract of 10 patients with phenylketonuria (PKU) and of two patients with hyperphenylalaninaemia were examined for reactivity toward the antibodies in crossed immunoelectrophoresis. In all patients phenylalanine hydroxylase could be detected. In nine out of 10 patients with PKU the mutant enzyme did not differ from the wild type enzyme with respect to the electrophoretic mobility. In one case the mutant enzyme had a more negative charge. In the patients with hyperphenylalaninaemia the enzyme of one patient had normal electrophoretic mobility and the enzyme of the other differed from the normal enzyme. No difference could be shown in heterozygotes for PKU.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0141-8955
pubmed:author
pubmed:issnType
Print
pubmed:volume
5
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
7-10
pubmed:dateRevised
2007-3-21
pubmed:meshHeading
pubmed:year
1982
pubmed:articleTitle
Studies on the molecular defect in phenylketonuria and hyperphenylalaninaemia using antibodies against phenylalanine hydroxylase.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't