Linked Life Data

6817723

Source:http://linkedlifedata.com/resource/pubmed/id/6817723

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1983-2-25
pubmed:abstractText
The concomitant protective effects of the aldose reductase inhibitor, 7-dimethylsulfamoyl-xanthone-2-carboxylic acid, were established by three lens parameters (soluble crystallin proteins, growth and cell hydration) because their quantitation provided a comprehensive index of lens physiology during sugar cataractogenesis in the rat neonate. Their fused eyelids provided the orbital pouch for topical administration of inhibitor to the treated lens; the contralateral pouch served as an untreated control. Protein preservation was determined by gel filtration chromatography. In galactose-maintained neonates, untreated lenses exhibited only 50% of the normal Fraction II protein whereas xanthone-treatment maintained 73% of this component. Quantitative analysis of scanning electron micrographs indicated that xanthone-treatment partially protected lenses against both intra and extracellular fluid accumulation as determined by measurements of individual fiber cell thickness, density (the number of cells/10 micron cortex), and interdigitation. In addition, xanthone-treatment improved lens growth as evidenced by radius and dry weight measurements. Our results suggest that topically applied xanthone partially inhibited sugar cataractogenesis.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0301-4533
pubmed:author
pubmed:issnType
Print
pubmed:volume
259
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
166-76
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1982
pubmed:articleTitle
Xanthone-2-carboxylic acid effect on lens growth, hydration and proteins during diabetic cataract development.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't