Linked Life Data

6817621

Source:http://linkedlifedata.com/resource/pubmed/id/6817621

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1983-2-14
pubmed:abstractText
E-N-L-Trimethyllysine glutamate (TML) influences the humoral and cellular immune response of mice. Chronic pre- and post-treatment (100 mg/kg/day, 5 times) transitionally increased the anti-SRBC haemagglutinin titre of female CBA mice. After 400 r whole body irradiation, TML treatment accelerated the normalization of the haemagglutinin level. TML treatment prolonged the life-span of BDF1 hybrid mice that had first been immunized and then inoculated with L1210 cells. TML diminished the delayed type hypersensitivity reaction in vivo of irradiated and non-irradiated CBA female mice and dose-dependent decreased the spontaneous (SLMC) and antibody-dependent (ADCC) cytotoxicity of healthy human lymphocytes, in vitro. As a low molecular weight immunomodulant, TML may also be considered as a therapeutic tool.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0065-4299
pubmed:author
pubmed:issnType
Print
pubmed:volume
12
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
503-7
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1982
pubmed:articleTitle
The effect of E-N-L-trimethyllysine (TML) on the humoral and cellular immune response.
pubmed:publicationType
Journal Article