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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
1983-2-14
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pubmed:abstractText |
In vitro studies were performed in two patients with B-cell chronic lymphocytic leukemia who developed pure red cell aplasia (CLL-PRCA). During the active phase of their red cell aplasia, there was a marked reduction in the numbers of erythroid colony-forming units (CFU-E). Unfractionated sera or separated IgG fractions from these patients did not impair CFU-E proliferation from either autologous or allogeneic marrows. Increased numbers of T lymphocytes were present in marrow aspirates of these patients. Analysis of these T cells indicated that 90 and 35%, respectively, bore Fc receptors for IgG (T gamma cells). Removal of T cells by E-rosetting techniques augmented CFU-E growth in CLL-PRCA 10-fold. Similar treatment of normal marrows did not cause similar enhanced growth of CFU-E. Co-cultures of marrow T cells or T gamma cells obtained during the active phase of CLL-PRCA suppressed CFU-E growth from autologous or allogeneic marrows. After achieving drug-induced remission of the PRCA, marrow T cells were no longer inhibitory. In contrast, BFU-E (erythroid burst-forming units) or granulocyte proliferation in diffusion chambers were not suppressed by CLL-PRCA T cells. These findings suggest that the development of PRCA in B-cell CLL may result from suppression of CFU-E proliferation by T gamma cells.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/6816810-1078982,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6816810-13212252,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6816810-13783288,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6816810-301544,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6816810-306845,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6816810-313223,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6816810-4415396,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6816810-4556902,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6816810-4604991,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6816810-4860750,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6816810-597564,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6816810-6445397,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6816810-6446683,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6816810-6457682,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6816810-6458339,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6816810-656632,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6816810-6785649,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6816810-686017,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6816810-6936262,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6816810-6967513,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6816810-6967904,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6816810-6970671,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6816810-6971120,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6816810-6971663,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6816810-6972322,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6816810-6978744,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6816810-6993560,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6816810-7042143,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6816810-7353071,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6816810-752263
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0021-9738
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
70
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1148-56
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:6816810-Anemia, Aplastic,
pubmed-meshheading:6816810-B-Lymphocytes,
pubmed-meshheading:6816810-Bone Marrow,
pubmed-meshheading:6816810-Cells, Cultured,
pubmed-meshheading:6816810-Colony-Forming Units Assay,
pubmed-meshheading:6816810-Erythropoiesis,
pubmed-meshheading:6816810-Humans,
pubmed-meshheading:6816810-Immunoglobulin gamma-Chains,
pubmed-meshheading:6816810-Leukemia, Lymphoid,
pubmed-meshheading:6816810-Receptors, Antigen, T-Cell,
pubmed-meshheading:6816810-T-Lymphocytes
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pubmed:year |
1982
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pubmed:articleTitle |
T gamma (T gamma) cells suppress growth of erythroid colony-forming units in vitro in the pure red cell aplasia of B-cell chronic lymphocytic leukemia.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
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