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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
12
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pubmed:dateCreated |
1983-1-19
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pubmed:abstractText |
Normal cycling virgin female Sprague-Dawley rats were divided into different treatment groups and subjected to half ad libitum feed intake for 2 or 4 weeks at consecutive periods of time before and/or after administration of 7,12-dimethylbenz(a)anthracene (DMBA) and then were returned to full-feed. All rats at the end of their respective under-feeding periods showed reductions in serum prolactin and cessation of estrous cycles. However, only rats underfed 1 week prior to and 1 week after DMBA administration showed significant reductions in mammary tumorigenesis or the entire 21 weeks of the experiment when compared to full-feed controls. Rat groups underfed during subsequent weeks after DMBA administration showed no alterations in mammary tumor development as compared to full-fed controls. These results demonstrate that inhibition and perhaps permanent suppression of mammary tumorigenesis occurred only in rats underfed 1 week before and 1 week after DMBA administration. The inhibitory effects produced by this under-feeding regimen on mammary tumorigenesis may be mediated by suppression of prolactin and estrogen secretion.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0008-5472
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
42
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
4943-7
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:6814746-9,10-Dimethyl-1,2-benzanthracene,
pubmed-meshheading:6814746-Animals,
pubmed-meshheading:6814746-Cell Division,
pubmed-meshheading:6814746-Female,
pubmed-meshheading:6814746-Kinetics,
pubmed-meshheading:6814746-Mammary Neoplasms, Experimental,
pubmed-meshheading:6814746-Nutrition Disorders,
pubmed-meshheading:6814746-Prolactin,
pubmed-meshheading:6814746-Rats,
pubmed-meshheading:6814746-Rats, Inbred Strains
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pubmed:year |
1982
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pubmed:articleTitle |
Influence of underfeeding during the "critical period" or thereafter on carcinogen-induced mammary tumors in rats.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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