Linked Life Data

6812105

Source:http://linkedlifedata.com/resource/pubmed/id/6812105

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1982-12-2
pubmed:abstractText
Caffeine and related alkylxanthines are widely used for recreation and therapeutic effects. In behavioral studies, both response rate-enhancing and attenuating effects have been described, depending upon the dose and behavioral measure used. Intracranial self-stimulation (ICSS) and differential reinforcement of low rates of responding (DRL) were assessed after rats were administered one of a range of doses of caffeine or aminophylline. These measures were chosen because of their demonstrated sensitivity to psychotropic drugs and the potential for comparing the alkylxanthine data to the extensive literature of amphetamine effects on ICSS and DRL behavior. Caffeine and aminophylline elicited dose- and drug-dependent changes in ICSS responding, and increased response rates and decreased reinforcements on the DRL schedule. These behavioral results are discussed with reference to alkylxanthine interactions with adenosine receptors.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0033-3158
pubmed:author
pubmed:issnType
Print
pubmed:volume
76
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
325-8
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1982
pubmed:articleTitle
Xanthines alter behavior maintained by intracranial electrical stimulation and an operant schedule.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.