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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
1982-12-2
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pubmed:abstractText |
Experiments were conducted to investigate the non-H-2 genetic effects on experimental autoimmune thyroiditis (EAT). Strains having C3H or BALB background in general produced higher autoimmune responses to mouse thyroglobulin (MTg) than the B10 or A strains. Comparisons of C3H and B10 congenic strains carrying similar H-2 haplotypes demonstrated that the C3H congenics had significantly higher MTg antibody titres and more severe thyroid damage, even when the strains carry the low responder H-2 haplotypes. These observations show that non-H-2 gene(s) influences EAT, in addition to genes in the MHC.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0305-1811
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
9
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
257-65
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:6811667-Animals,
pubmed-meshheading:6811667-Antibody Formation,
pubmed-meshheading:6811667-Autoimmune Diseases,
pubmed-meshheading:6811667-Dose-Response Relationship, Immunologic,
pubmed-meshheading:6811667-Genes, MHC Class II,
pubmed-meshheading:6811667-H-2 Antigens,
pubmed-meshheading:6811667-Mice,
pubmed-meshheading:6811667-Mice, Inbred A,
pubmed-meshheading:6811667-Mice, Inbred BALB C,
pubmed-meshheading:6811667-Mice, Inbred C3H,
pubmed-meshheading:6811667-Mice, Inbred C57BL,
pubmed-meshheading:6811667-Species Specificity,
pubmed-meshheading:6811667-Thyroglobulin,
pubmed-meshheading:6811667-Thyroiditis
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pubmed:year |
1982
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pubmed:articleTitle |
Regulation of experimental autoimmune thyroiditis: influence of non-H-2 genes.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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