| pubmed-article:6809941 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:6809941 | lifeskim:mentions | umls-concept:C0014834 | lld:lifeskim |
| pubmed-article:6809941 | lifeskim:mentions | umls-concept:C0022940 | lld:lifeskim |
| pubmed-article:6809941 | lifeskim:mentions | umls-concept:C0034289 | lld:lifeskim |
| pubmed-article:6809941 | lifeskim:mentions | umls-concept:C0039667 | lld:lifeskim |
| pubmed-article:6809941 | lifeskim:mentions | umls-concept:C0021467 | lld:lifeskim |
| pubmed-article:6809941 | lifeskim:mentions | umls-concept:C0206755 | lld:lifeskim |
| pubmed-article:6809941 | lifeskim:mentions | umls-concept:C1707455 | lld:lifeskim |
| pubmed-article:6809941 | lifeskim:mentions | umls-concept:C0021469 | lld:lifeskim |
| pubmed-article:6809941 | lifeskim:mentions | umls-concept:C0009601 | lld:lifeskim |
| pubmed-article:6809941 | lifeskim:mentions | umls-concept:C0936012 | lld:lifeskim |
| pubmed-article:6809941 | lifeskim:mentions | umls-concept:C0887819 | lld:lifeskim |
| pubmed-article:6809941 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:6809941 | pubmed:dateCreated | 1982-10-21 | lld:pubmed |
| pubmed-article:6809941 | pubmed:abstractText | The inhibition constants (Kiapp) obtained from the action of 44 2,4-diamino-5-(substituted-benzyl)pyrimidines on dihydrofolate reductase (DHFR) from Escherichia coli and Lactobacillus casei bacteria are used to derive quantitative structure-activity relationships (QSAR). These equations bring out a number of differences in the DHFR which can be understood at the atomic level by studying color stereo computer graphics models constructed from the X-ray coordinates of the enzyme-inhibitor complexes. The combination of QSAR and X-ray crystallography interpreted via high-performance computer graphics offers a new level of sophistication to extend our understanding of enzyme-ligand interactions, which, when the crystallography is known, opens up a more scientific approach to drug development. | lld:pubmed |
| pubmed-article:6809941 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6809941 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6809941 | pubmed:language | eng | lld:pubmed |
| pubmed-article:6809941 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6809941 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:6809941 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6809941 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6809941 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:6809941 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:6809941 | pubmed:issn | 0022-2623 | lld:pubmed |
| pubmed-article:6809941 | pubmed:author | pubmed-author:FAYE LEL | lld:pubmed |
| pubmed-article:6809941 | pubmed:author | pubmed-author:HanschCC | lld:pubmed |
| pubmed-article:6809941 | pubmed:author | pubmed-author:BlaneyJ MJM | lld:pubmed |
| pubmed-article:6809941 | pubmed:author | pubmed-author:LangridgeRR | lld:pubmed |
| pubmed-article:6809941 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:6809941 | pubmed:volume | 25 | lld:pubmed |
| pubmed-article:6809941 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:6809941 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:6809941 | pubmed:pagination | 777-84 | lld:pubmed |
| pubmed-article:6809941 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:6809941 | pubmed:meshHeading | pubmed-meshheading:6809941-... | lld:pubmed |
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| pubmed-article:6809941 | pubmed:meshHeading | pubmed-meshheading:6809941-... | lld:pubmed |
| pubmed-article:6809941 | pubmed:meshHeading | pubmed-meshheading:6809941-... | lld:pubmed |
| pubmed-article:6809941 | pubmed:meshHeading | pubmed-meshheading:6809941-... | lld:pubmed |
| pubmed-article:6809941 | pubmed:meshHeading | pubmed-meshheading:6809941-... | lld:pubmed |
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| pubmed-article:6809941 | pubmed:meshHeading | pubmed-meshheading:6809941-... | lld:pubmed |
| pubmed-article:6809941 | pubmed:meshHeading | pubmed-meshheading:6809941-... | lld:pubmed |
| pubmed-article:6809941 | pubmed:year | 1982 | lld:pubmed |
| pubmed-article:6809941 | pubmed:articleTitle | Comparison of the inhibition of Escherichia coli and Lactobacillus casei dihydrofolate reductase by 2,4-diamino-5-(substituted-benzyl)pyrimidines: quantitative structure-activity relationships, X-ray crystallography, and computer graphics in structure-activity analysis. | lld:pubmed |
| pubmed-article:6809941 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:6809941 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:6809941 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:6809941 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | http://linkedlifedata.com/r... | pubmed-article:6809941 | lld:chembl |
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