Linked Life Data

6809906

Source:http://linkedlifedata.com/resource/pubmed/id/6809906

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8
pubmed:dateCreated
1982-10-21
pubmed:abstractText
The distribution and regulation of the state of phosphorylation of Protein I have been studied in the rabbit superior cervical sympathetic ganglion. The data indicate that the ganglion contains two pools of Protein I: a presynaptic pool that represents 60% of the total ganglion Protein I and a postsynaptic pool that represents 40% of the total ganglion Protein I. The state of phosphorylation of presynaptic Protein I, but not that of postsynaptic Protein I, is regulated by nerve impulse conduction, by dopamine, and by a high K+ concentration. Studies of the extracellular calcium requirements for Protein I phosphorylation, as well as peptide-mapping analyses of Protein I, suggest that the effects of nerve impulse conduction and of a high K+ concentration are mediated through the activation of calcium-dependent protein kinases and that the effect of dopamine is mediated through the activation of cyclic AMP-dependent protein kinase. The total amount of postsynaptic Protein I, but not that of presynaptic Protein I, is decreased by short periods of exposure to cycloheximide, a protein synthesis inhibitor. It is proposed that Protein I located in presynaptic nerve terminals plays a functional role in those terminals and that the Protein I located in cell bodies is newly synthesized and en route to nerve terminals.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0270-6474
pubmed:author
pubmed:issnType
Print
pubmed:volume
2
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1011-23
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1982
pubmed:articleTitle
Distribution of protein I and regulation of its state of phosphorylation in the rabbit superior cervical ganglion.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't