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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3-4
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pubmed:dateCreated |
1982-9-17
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pubmed:abstractText |
Abdominal aorta ligation in neonatal rats was used as a model for pediatric traumatic injury. Short-term ischemic trauma (24 h) was found to have significant effect on plasma corticosterone levels, and on the specific activity of the drug-metabolizing enzymes FAD-containing monooxygenase and glucuronyl transferase in hepatic microsomes. Ischemic injury was determined to cause a decrease in FAD-containing monooxygenase activity in pre-weaning animals. Glucuronyl transferase activity was increased by this surgical procedure in animals less than 12 days age, and after weaning; however, glucuronyl transferase activity was decreased by this model in rats between 14 days of age and weaning.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0378-4274
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
11
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
259-67
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:6808709-Animals,
pubmed-meshheading:6808709-Animals, Newborn,
pubmed-meshheading:6808709-Aorta, Abdominal,
pubmed-meshheading:6808709-Blood Vessels,
pubmed-meshheading:6808709-Corticosterone,
pubmed-meshheading:6808709-Female,
pubmed-meshheading:6808709-Glucuronosyltransferase,
pubmed-meshheading:6808709-Liver,
pubmed-meshheading:6808709-Male,
pubmed-meshheading:6808709-Microsomes, Liver,
pubmed-meshheading:6808709-Mixed Function Oxygenases,
pubmed-meshheading:6808709-Oxidoreductases,
pubmed-meshheading:6808709-Rats,
pubmed-meshheading:6808709-Rats, Inbred Strains
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pubmed:year |
1982
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pubmed:articleTitle |
Effect of model vascular trauma on the hepatic drug-metabolizing enzymes of the neonatal rat.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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