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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
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pubmed:dateCreated |
1982-9-24
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pubmed:abstractText |
Chronic treatment of rats with the antipsychotic drug molindone (2.5 mg/kg) did not elicit behavioral supersensitivity to apomorphine (AP) (0.25 mg/kg) or increased striatal 3H-spiroperidol binding, whereas treatment with haloperidol (0.5-1.0 mg/kg) produced manifestations of dopaminergic supersensitivity in both paradigms. Chronic treatment with a high dose of molindone (20 mg/kg) elicited a small, but significant increase in behavioral sensitivity to AP (57%) which was, however, significantly less than that produced by 1 mg/kg haloperidol (126%, P less than 0.01). Apparent tolerance to elevation of striatal and frontal cortical 3,4-dihydroxyphenylacetic acid (DOPAC) levels was obtained with chronic molindone treatment (5 or 20 mg/kg). None of the molindone doses used (2.5-50 mg/kg) increased striatal dopamine receptor binding. Scatchard analyses revealed no change in either maximal binding capacity (Bmax) or dissociation constant (Kd). A significant (P less than 0.001) correlation of receptor binding activity and stereotypy score was obtained for haloperidol-, but not molindone-treated rats. These results with molindone in an animal model of tardive dyskinesia suggest that this drug may have a lower potential for eliciting this disorder in humans.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/3,4-Dihydroxyphenylacetic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Haloperidol,
http://linkedlifedata.com/resource/pubmed/chemical/Indoles,
http://linkedlifedata.com/resource/pubmed/chemical/Molindone,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Dopamine,
http://linkedlifedata.com/resource/pubmed/chemical/Spiperone
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pubmed:status |
MEDLINE
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pubmed:issn |
0033-3158
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
76
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
222-7
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:6808540-3,4-Dihydroxyphenylacetic Acid,
pubmed-meshheading:6808540-Animals,
pubmed-meshheading:6808540-Behavior, Animal,
pubmed-meshheading:6808540-Binding, Competitive,
pubmed-meshheading:6808540-Corpus Striatum,
pubmed-meshheading:6808540-Haloperidol,
pubmed-meshheading:6808540-Humans,
pubmed-meshheading:6808540-Indoles,
pubmed-meshheading:6808540-Male,
pubmed-meshheading:6808540-Molindone,
pubmed-meshheading:6808540-Rats,
pubmed-meshheading:6808540-Rats, Inbred Strains,
pubmed-meshheading:6808540-Receptors, Dopamine,
pubmed-meshheading:6808540-Spiperone,
pubmed-meshheading:6808540-Stereotyped Behavior,
pubmed-meshheading:6808540-Time Factors
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pubmed:year |
1982
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pubmed:articleTitle |
Chronic molindone treatment: relative inability to elicit dopamine receptor supersensitivity in rats.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.
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