Linked Life Data

6807535

Source:http://linkedlifedata.com/resource/pubmed/id/6807535

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8
pubmed:dateCreated
1982-9-10
pubmed:abstractText
The role of polyamines during the process of colony-stimulating factor-induced proliferation and differentiation of human granulocyte-macrophage progenitor cells was studied using in vitro liquid cultures and semisolid agar cultures. Human placenta-conditioned medium, a partially purified preparation of colony-stimulating factor, rapidly and significantly increased the intracellular putrescine concentration of light-density, non-adherent, T-lymphocyte-depleted human marrow cells, Inhibition of polyamine biosynthesis with alpha-difluoromethylornithine, a catalytic, irreversible inhibitor or ornithine decarboxylase, resulted in an accumulation of blasts, promyelocytes, and myelocytes with a concomitant decrease in metamyelocytes and polymorphonuclear granulocytes, suggesting a granulopoietic differentiation block. The observed inhibition of differentiation could easily be reversed with exogenously added putrescine. These data indicate clearly an essential role for polyamines during the process of human granulopoietic differentiation.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0008-5472
pubmed:author
pubmed:issnType
Print
pubmed:volume
42
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
3046-9
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1982
pubmed:articleTitle
An essential role for polyamine biosynthesis during human granulopoietic differentiation.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't