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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
7
|
| pubmed:dateCreated |
1982-8-14
|
| pubmed:abstractText |
The effects of theophylline and melanocyte-stimulating hormone on B16 melanoma cells in culture cells were studied by electron microscopy and dopa cytochemistry. The data show that theophylline and melanocyte-stimulating hormone enhance melanogenesis by activating tyrosinase synthesis and its transfer but that neither affects the synthesis of the well-organized eumelanosome matrix. Their pigmenting effects appear to be limited to the melanogenic cells and result from a marked increase, particularly in theophylline-treated cells, in pheomelanosome formation.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jul
|
| pubmed:issn |
0008-5472
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
42
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
2786-91
|
| pubmed:dateRevised |
2007-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:6805946-Animals,
pubmed-meshheading:6805946-Cell Line,
pubmed-meshheading:6805946-Cells, Cultured,
pubmed-meshheading:6805946-Dihydroxyphenylalanine,
pubmed-meshheading:6805946-Melanocyte-Stimulating Hormones,
pubmed-meshheading:6805946-Melanoma,
pubmed-meshheading:6805946-Mice,
pubmed-meshheading:6805946-Mice, Inbred C57BL,
pubmed-meshheading:6805946-Neoplasms, Experimental,
pubmed-meshheading:6805946-Theophylline
|
| pubmed:year |
1982
|
| pubmed:articleTitle |
Electron microscopic and cytochemical observations of theophylline and melanocyte-stimulating hormone effects on melanoma cells in culture.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|