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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
|
| pubmed:dateCreated |
1982-7-19
|
| pubmed:abstractText |
The influence on human urate homeostasis of prolonged, totally purine-free nutritional support, using total parenteral (TPN) or elemental enteral (EN) nutrition, is not well known. In a prospective study, we measured weekly serum uric acid, renal urate excretion and clearance, together with parameters of hydration, in 58 normally hydrated patients receiving prolonged (15 to 170 days) purine-free TPN (30 patients) or EN (28 patients) for various gastrointestinal disorders. A marked, early and sustained decrease (p less than 0.001) in serum uric acid was observed in TPN (155 +/- 9 mumol/l at day 7 versus 318 +/- 13 mumol/l before nutrition, mean +/- SEM) as well as in EN patients (192 +/- 11 mumol/l at day 7 versus 320 +/- 16 mumol/l before nutrition), together with a significant (p less than 0.01) rise in renal urate clearance. The urate clearance/glomerular filtration rate ratio increased significantly, while there was no significant change in natremia or plasma osmolarity. Serum urate and urate clearance returned to normal within 8 days of refeeding with a normally purine-containing diet. Replacement of TPN by EN or vice versa, or substitution of glucose by fructose resulted in no change in hypouricemia. A 4-day oral supply of purines (125 mg/day) in EN patients was associated with a 53% rise (p less than 0.01) in serum urate. We conclude that prolonged, purine-free TPN and elemental EN are a new cause of marked hypouricemia which is mainly due to increased urate clearance, the mechanism of the latter is still poorly known, but is not related to extracellular volume expansion.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Fructose,
http://linkedlifedata.com/resource/pubmed/chemical/Glucose,
http://linkedlifedata.com/resource/pubmed/chemical/Purines,
http://linkedlifedata.com/resource/pubmed/chemical/Sodium,
http://linkedlifedata.com/resource/pubmed/chemical/Uric Acid
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
May
|
| pubmed:issn |
0002-9165
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
35
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
997-1002
|
| pubmed:dateRevised |
2004-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:6805292-Adolescent,
pubmed-meshheading:6805292-Adult,
pubmed-meshheading:6805292-Aged,
pubmed-meshheading:6805292-Enteral Nutrition,
pubmed-meshheading:6805292-Female,
pubmed-meshheading:6805292-Fructose,
pubmed-meshheading:6805292-Gastrointestinal Diseases,
pubmed-meshheading:6805292-Glomerular Filtration Rate,
pubmed-meshheading:6805292-Glucose,
pubmed-meshheading:6805292-Homeostasis,
pubmed-meshheading:6805292-Humans,
pubmed-meshheading:6805292-Male,
pubmed-meshheading:6805292-Middle Aged,
pubmed-meshheading:6805292-Parenteral Nutrition,
pubmed-meshheading:6805292-Parenteral Nutrition, Total,
pubmed-meshheading:6805292-Purines,
pubmed-meshheading:6805292-Sodium,
pubmed-meshheading:6805292-Time Factors,
pubmed-meshheading:6805292-Uric Acid
|
| pubmed:year |
1982
|
| pubmed:articleTitle |
Effects of prolonged, purine-free total parenteral and enteral nutrition on urate homeostasis in man.
|
| pubmed:publicationType |
Journal Article
|