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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
1982-6-21
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pubmed:abstractText |
1. The transmural electrical potential difference (PD) of the intact human small intestine was recorded with close attention to electrical symmetry, shielding from electro-magnetic waves and correction for junction potentials. 2. The PD is -12 mV (mucosa-negative) in the fasting jejunum and ileum and does not change during perfusion with isotonic NaCl. 3. Absorption of Na and Cl appears to be non-electrogenic and the 'resting' PD is probably generated by active anion secretion of fasting intestinal contents. 4. Diffusion potentials during isotonic D-mannitol perfusion indicated higher cation selectivity in the ileum than in the jejunum. 5. The calculated contribution of a free-solution path to total paracellular permeability is 55% in the jejunum but only 15% in the ileum. 6. No 'streaming' potential was detected during osmotic water flow, suggesting that the cation-selectivity of the channels is temporarily inactivated during dilatation of the lateral intercellular space.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/6802960-1080796,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6802960-1245284,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6802960-18128147,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6802960-181580,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6802960-395308,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6802960-437420,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6802960-4473455,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6802960-4546135,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6802960-4825690,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6802960-5058963,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6802960-5415681,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6802960-5415682,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6802960-5439136,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6802960-5441389,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6802960-5635768,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6802960-5690243,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6802960-5766908,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6802960-5773917,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6802960-590846,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6802960-5943002,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6802960-5958608,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6802960-5972215,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6802960-599551,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6802960-6061361,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6802960-6777399,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6802960-852747,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6802960-856673
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0022-3751
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
321
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
571-82
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pubmed:dateRevised |
2010-9-13
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pubmed:meshHeading |
pubmed-meshheading:6802960-Adult,
pubmed-meshheading:6802960-Humans,
pubmed-meshheading:6802960-Hypertonic Solutions,
pubmed-meshheading:6802960-Intestinal Mucosa,
pubmed-meshheading:6802960-Intestine, Small,
pubmed-meshheading:6802960-Isotonic Solutions,
pubmed-meshheading:6802960-Kinetics,
pubmed-meshheading:6802960-Mannitol,
pubmed-meshheading:6802960-Membrane Potentials,
pubmed-meshheading:6802960-Middle Aged,
pubmed-meshheading:6802960-Osmolar Concentration,
pubmed-meshheading:6802960-Perfusion
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pubmed:year |
1981
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pubmed:articleTitle |
Human intestinal potential difference: recording method and biophysical implications.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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