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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6319
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pubmed:dateCreated |
1982-6-21
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pubmed:abstractText |
Anti-D IgG was injected into 15 Rh-negative women in the 28th week of gestation and into three non-pregnant women. The uptake of anti-D after the intramuscular injections was calculated by measuring the concentration of antibody in the plasma with an autoanalyser. The biological half life and the catabolic rate of anti-D IgG were calculated according to a compartmental model. The recovery in vivo of anti-D was an average 24% in the non-pregnant women and 21% in the pregnant women. The half life of anti-D were 24 and 21 days, respectively. With a dose of 125 micrograms the plasma anti-D concentration was less than 1 ng/ml at about 10 weeks after the injection. With double the dose the concentration at delivery was at least 1 ng/ml. Although 250 micrograms of anti-D IgG seems to be effective when given in the 28th weeks of gestation, the great individual variations in uptake and recovery rates will lead to occasional cases of Rh-immunisation during pregnancy despite all routine regimens.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/6802325-13671094,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6802325-13694426,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6802325-14059837,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6802325-14144524,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6802325-4113191,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6802325-4998530,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6802325-5693779,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6802325-6158170,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6802325-7426512,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6802325-77714,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6802325-77715,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6802325-816170
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0267-0623
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
20
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pubmed:volume |
284
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
854-5
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
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pubmed:year |
1982
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pubmed:articleTitle |
Turnover rate of anti-D IgG injected during pregnancy.
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pubmed:publicationType |
Journal Article
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