Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1982-5-21
pubmed:abstractText
Laboratory mice with genetic or induced immunodeficiencies were vaccinated with irradiated cercariae of Schistosoma mansoni and assayed 4 wk later for their resistance to challenge infection. Athymic nude mice failed to develop immunity to challenge or detectable antibody responses to schistosomula, whereas heterozygote (nu/+) controls and nude mice with thymus grafts displayed highly significant levels of resistance and anti-schistosomulum antibody. Similarly, no resistance or antibody production as observed in vaccinated mice that had been made deficient in B lymphocytes by the injection of anti-mu-chain antisera from birth. In contrast, normal levels of vaccine-induced resistance were observed in mice genetically deficient in the fifth component of complement (C5) and in mice decomplemented before challenge by treatment with cobra venom factor. These results indicate that the resistance to challenge infection induced by irradiated cercariae is both thymus and B lymphocyte dependent and therefore is likely to result from specific immune responses directed against schistosome worms. The data also argue against a role for complement in the effector mechanism of vaccine-induced immunity.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0022-1767
pubmed:author
pubmed:issnType
Print
pubmed:volume
128
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1880-4
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:6801124-Animals, pubmed-meshheading:6801124-Antibody Formation, pubmed-meshheading:6801124-B-Lymphocytes, pubmed-meshheading:6801124-Cell Differentiation, pubmed-meshheading:6801124-Cobra Venoms, pubmed-meshheading:6801124-Complement System Proteins, pubmed-meshheading:6801124-Female, pubmed-meshheading:6801124-Immunity, Cellular, pubmed-meshheading:6801124-Immunoglobulin M, pubmed-meshheading:6801124-Immunoglobulin mu-Chains, pubmed-meshheading:6801124-Immunologic Deficiency Syndromes, pubmed-meshheading:6801124-Mice, pubmed-meshheading:6801124-Mice, Inbred BALB C, pubmed-meshheading:6801124-Mice, Inbred C57BL, pubmed-meshheading:6801124-Mice, Nude, pubmed-meshheading:6801124-Schistosoma mansoni, pubmed-meshheading:6801124-Schistosomiasis, pubmed-meshheading:6801124-T-Lymphocytes, pubmed-meshheading:6801124-Thymus Gland, pubmed-meshheading:6801124-Vaccination
pubmed:year
1982
pubmed:articleTitle
Mechanisms of protective immunity against Schistosoma mansoni infection in mice vaccinated with irradiated cercariae. II. Analysis of immunity in hosts deficient in T lymphocytes, B lymphocytes, or complement.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't