Linked Life Data

6799885

Source:http://linkedlifedata.com/resource/pubmed/id/6799885

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1982-4-12
pubmed:abstractText
A stable model has been developed for oral mucosal anaplastic epidermoid carcinoma. This model more closely resembles the biologic characteristics of human oral carcinoma than previous models, such as primary epidermoid carcinomas induced in hamster buccal pouches or tongue by chemical carcinogens. This anaplastic oral cancer model was developed by serial abdominal transplantation in neonatal hamsters of original DMBA-induced primary epidermoid carcinomas of hamster buccal pouch. After the second generation, the tumors became stable, maintained an anaplastic appearance histologically, and were biologically aggressive, with rapid growth and metastatic potential. The original DMBA-induced buccal pouch tumors from 42 adult hamsters were transplanted abdominally through five generations in 151 neonatal hamsters. Immunosuppression was crucial in the initial transplantation but became unnecessary in the later serial transplantations. This model can serve as the basis for a variety of future immunologic and biologic studies dealing with oral cancer.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
D
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0030-4220
pubmed:author
pubmed:issnType
Print
pubmed:volume
53
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
179-89
pubmed:dateRevised
2005-11-17
pubmed:meshHeading
pubmed:year
1982
pubmed:articleTitle
A transplantable anaplastic oral cancer model.
pubmed:publicationType
Journal Article