Linked Life Data

6799206

Source:http://linkedlifedata.com/resource/pubmed/id/6799206

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1 Pt 1
pubmed:dateCreated
1982-4-12
pubmed:abstractText
Hemin enhances the adipose differentiation of mouse 3T3-F442A cells in a medium containing high levels of adipogenic factor that is present in fetal calf serum or calf serum. This enhancement is more prominent in the presence of insulin. Hemin also promotes adipose differentiation in a medium containing 10% cat serum, which has very little adipogenic factor; this effect is in contrast to that of insulin, which is relatively ineffective in promoting adipose differentiation in this medium. Adipose differentiation of 3T3-F442A cells is inhibited by the addition of aminotriazole, an inhibitor of heme biosynthesis. The inhibition of adipose differentiation by aminotriazole is prevented by the simultaneous addition of hemin and aminotriazole. These results indicate that treatment with hemin can promote the differentiation of fibroblasts to adipocytes in vitro, and they raise the possibility that endogenous heme may have a physiological role in the differentiation of fibroblasts to adipocytes in vivo.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0092-8674
pubmed:author
pubmed:issnType
Print
pubmed:volume
26
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
117-22
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed:year
1981
pubmed:articleTitle
Hemin enhances the differentiation of mouse 3T3 cells to adipocytes.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.