|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
4
|
|
pubmed:dateCreated |
1982-3-13
|
|
pubmed:abstractText |
Platelets from vitamin E-deficient and vitamin E-supplemented rats generate the same amount of thromboxane A2 (TxA2) when they are incubated with unesterified arachidonic acid. Platelets from vitamin E-deficient rats produced more TxA2 than platelets from vitamin E-supplemented rats when the platelets are challenged with collagen. Arterial tissue from vitamin E-deficient rats generates less prostacyclin (PGI2) than arterial tissue from vitamin E- supplemented rats. The vitamin E effect with arterial tissue is observed when the tissue is incubated with and without added unesterified arachidonic acid. These data show that arterial prostacyclin synthesis is diminished in vitamin E-deficient rats. Vitamin E, in vivo, inhibits platelet aggregation both by lowering platelet TxA2 and by raising arterial PGI2.
|
|
pubmed:grant |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Oct
|
|
pubmed:issn |
0090-6980
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
22
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
651-61
|
|
pubmed:dateRevised |
2007-11-14
|
|
pubmed:meshHeading |
pubmed-meshheading:6798639-Adenosine Diphosphate,
pubmed-meshheading:6798639-Animals,
pubmed-meshheading:6798639-Aorta,
pubmed-meshheading:6798639-Arachidonic Acid,
pubmed-meshheading:6798639-Arachidonic Acids,
pubmed-meshheading:6798639-Blood Platelets,
pubmed-meshheading:6798639-Collagen,
pubmed-meshheading:6798639-Epoprostenol,
pubmed-meshheading:6798639-Male,
pubmed-meshheading:6798639-Prostaglandins,
pubmed-meshheading:6798639-Rats,
pubmed-meshheading:6798639-Rats, Inbred Strains,
pubmed-meshheading:6798639-Thromboxane A2,
pubmed-meshheading:6798639-Thromboxanes,
pubmed-meshheading:6798639-Vitamin E,
pubmed-meshheading:6798639-Vitamin E Deficiency
|
|
pubmed:year |
1981
|
|
pubmed:articleTitle |
Modulation of Platelet thromboxane A2 and arterial prostacyclin by dietary vitamin E.
|
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|
