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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
1982-1-28
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pubmed:abstractText |
Hepatic microsomal monooxygenase induction was investigated in young-adult and middle-aged male Fischer 344 rats. Monooxygenase components and drug metabolism activities were determined in liver microsomes prepared from rats treated with phenobarbital (PB, beta-naphthoflavone (BNF) or methyltestosterone (MT) and compared with values from untreated rats. PB and BNF effects on cytochrome P-450 concentration and cytochrome c reductase activity were similar in young-adult and middle-aged animals. However, the extent of cytochrome P-450 induction by MT was less in the older animals. The age-related changes in induction of drug metabolism activities differed with different substrates for the monooxygenase system. In contrast to the inducibility of benzphetamine N-demethylation and aniline hydroxylation, which was diminished in the older rats, the inducibility of nitroanisole O-demethylation was enhanced. The results imply that qualitative changes in the microsomal enzyme system occurred as the animals progress from young to middle adulthood.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Aniline Hydroxylase,
http://linkedlifedata.com/resource/pubmed/chemical/Benzoflavones,
http://linkedlifedata.com/resource/pubmed/chemical/Cytochrome P-450 Enzyme System,
http://linkedlifedata.com/resource/pubmed/chemical/Methyltestosterone,
http://linkedlifedata.com/resource/pubmed/chemical/Mixed Function Oxygenases,
http://linkedlifedata.com/resource/pubmed/chemical/NADPH-Ferrihemoprotein Reductase,
http://linkedlifedata.com/resource/pubmed/chemical/Nitroanisole O-Demethylase,
http://linkedlifedata.com/resource/pubmed/chemical/Oxidoreductases, N-Demethylating,
http://linkedlifedata.com/resource/pubmed/chemical/Phenobarbital,
http://linkedlifedata.com/resource/pubmed/chemical/benzphetamine N-demethylase,
http://linkedlifedata.com/resource/pubmed/chemical/beta-Naphthoflavone
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pubmed:status |
MEDLINE
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pubmed:issn |
0047-6374
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
16
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
371-8
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:6795400-Aging,
pubmed-meshheading:6795400-Aniline Hydroxylase,
pubmed-meshheading:6795400-Animals,
pubmed-meshheading:6795400-Benzoflavones,
pubmed-meshheading:6795400-Cytochrome P-450 Enzyme System,
pubmed-meshheading:6795400-Enzyme Induction,
pubmed-meshheading:6795400-Male,
pubmed-meshheading:6795400-Methyltestosterone,
pubmed-meshheading:6795400-Microsomes, Liver,
pubmed-meshheading:6795400-Mixed Function Oxygenases,
pubmed-meshheading:6795400-NADPH-Ferrihemoprotein Reductase,
pubmed-meshheading:6795400-Nitroanisole O-Demethylase,
pubmed-meshheading:6795400-Oxidoreductases, N-Demethylating,
pubmed-meshheading:6795400-Phenobarbital,
pubmed-meshheading:6795400-Rats,
pubmed-meshheading:6795400-Rats, Inbred F344,
pubmed-meshheading:6795400-beta-Naphthoflavone
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pubmed:year |
1981
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pubmed:articleTitle |
Substrate specificity of age-related changes in the inducibility of hepatic microsomal monooxygenases in middle-aged rats.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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