Linked Life Data

6795137

Source:http://linkedlifedata.com/resource/pubmed/id/6795137

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
9
pubmed:dateCreated
1982-1-20
pubmed:abstractText
Activation of spleen cell cultures by T-cell mitogens appeared enhanced or suppressed by the presence of some nonsteroid anti-inflammatory drugs such as indomethacin and indomethacin esters in a dose-dependent fashion. However blastogenesis of B cells by bacterial lipopolysaccharide was inhibited by the same drugs at every concentration tested. In vivo treatment of mice with indomethacin led to an inhibition of both T and B lymphocyte responses to mitogens. Addition of indomethacin to Concanavalin A-stimulated spleen cells from indomethacin-treated mice further inhibited the response to the mitogen. Indomethacin and indomethacin esters induced only a slight inhibition of cell-mediated cytotoxic reactions when added to cultures, whereas these reactions were markedly inhibited in spleen cells from indomethacin-treated mice.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0174-4879
pubmed:author
pubmed:issnType
Print
pubmed:volume
19
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
420-4
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1981
pubmed:articleTitle
Variable effects of indomethacin and four related compounds on lymphocyte blastogenesis and cell-mediated cytotoxicity.
pubmed:publicationType
Journal Article, Comparative Study, In Vitro, Research Support, Non-U.S. Gov't