Linked Life Data

6789783

Source:http://linkedlifedata.com/resource/pubmed/id/6789783

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1981-9-15
pubmed:abstractText
Adult male rats were exposed to 0.5% manganese as MnCl2 in their drinking water for 1, 4, or 6 weeks. Manganese content was measured in brain, liver, kidney, and intestine. Peak manganese concentrations were found in all tissues after one week exposure. Hepatic aryl hydrocarbon hydroxylase, ethoxycoumarin O-deethylase, and epoxide hydrase activities increased after one week manganese exposure, while intestinal and renal activities decreased. The activities returned nearly to the control level at six weeks of exposure. The UDPglucuronosyltransferase activity increased in the liver, kidney, and intestinal mucosa after one week exposure, decreasing thereafter nearly to the control level. In the brain, most significant changes were found after six weeks exposure when the succinate dehydrogenase activity decreased. The results suggest an adaptation to manganese absorption during continuous exposure. The biotransformation enzymes respond first to manganese exposure followed by neurochemical changes in the central nervous system.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0090-4341
pubmed:author
pubmed:issnType
Print
pubmed:volume
10
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
339-45
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed:year
1981
pubmed:articleTitle
Neurochemical and biotransformational enzyme responses to manganese exposure in rats.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.