Linked Life Data

6789223

Source:http://linkedlifedata.com/resource/pubmed/id/6789223

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1981-9-22
pubmed:abstractText
The author reports the results of quantitative and qualitative investigations of immunoglobulins in the cerebrospinal fluid in multiple sclerosis and their evaluation in the aspect of their diagnostic usefulness. Determinations of the relative Ig level and the IgG index were of greater diagnostic usefulness than determinations of absolute Ig level. Already determination of the absolute level was valuable in cases with normal total protein level in the fluid. The results of quantitative determinations of Ig in the fluid were insufficient, however, for differential diagnosis against the group of diseases with local Ig production. Evaluation of the oligoclonal character of Ig in the fluid based on electrophoretic separation in agar and agarose was very useful in the diagnosis, but this phenomenon occurs also in a limited group of other central nervous system diseases. The abnormal ratio of kappa to lambda chains in the cerebrospinal fluid is of decisive importance for the diagnosis of multiple sclerosis. Complex quantitative and qualitative determinations of Ig in the cerebrospinal fluid are a significant advance in the diagnosis of multiple sclerosis making possible the correct diagnosis in cases with monosymptomatic or oligosymptomatic onset already in the first stage of the disease, and also in clinically silent periods e.g. before the first phase of the disease.
pubmed:language
pol
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0028-3843
pubmed:author
pubmed:issnType
Print
pubmed:volume
15
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
5-16
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:articleTitle
[Diagnostic value of quantitative and qualitative studies of cerebrospinal fluid immunoglobulins in multiple sclerosis].
pubmed:publicationType
Journal Article, English Abstract