Linked Life Data

6788395

Source:http://linkedlifedata.com/resource/pubmed/id/6788395

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
12
pubmed:dateCreated
1981-9-15
pubmed:abstractText
The antiestrogen of the triphenylethylene type, Taxomifen (Tx), exerts its inhibitory action on cell multiplication of the human breast cancer cell line MCF-7 in the complete absence of estrogens in the culture medium. These cells contain saturable, high affinity (KA = 7 x 10(8) LM(-1)) binding sites for Tx and specific for antiestrogens (12,000 sites/cell). The concentration of these sites is significantly decreased in Tx-resistant variants of this cell line (2,700 sites/cell). In contrast, the concentration of estrogen receptors is similar in this population of variants and in the wild population (43,000 and 48,000 sites/cell respectively). These data support the concept of a role of these antiestrogen binding sites in the molecular mechanism controlling the multiplication of these breast cancer cells.
pubmed:language
fre
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0249-6313
pubmed:author
pubmed:issnType
Print
pubmed:day
23
pubmed:volume
292
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
767-70
pubmed:dateRevised
2008-2-22
pubmed:meshHeading
pubmed:year
1981
pubmed:articleTitle
[Mechanism of action of a triphenylethylene type antiestrogen on growth of the human breast cancer cell line. MCF-7 in culture].
pubmed:publicationType
Journal Article, English Abstract