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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
5
|
pubmed:dateCreated |
1981-7-9
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pubmed:abstractText |
We review hereditary influences in the epilepsies from the perspective of medical genetics. The recurrence risk for epilepsy in close relatives may vary from 2% to 5% up to 50% depending on the etiology of the seizure disorder in the proband. We emphasize the identification of specific disorders with single-gene inheritance that will lead to useful conclusions regarding treatment, prognosis, and family counseling. Also discussed are chromosomal aberrations, polygenic inheritance, gene-environment interactions, animal models of epilepsy, and the pharmacogenetics of anticonvulsants.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
AIM
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pubmed:status |
MEDLINE
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pubmed:month |
May
|
pubmed:issn |
0002-922X
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pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
135
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
|
pubmed:pagination |
450-7
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:6786088-Animals,
pubmed-meshheading:6786088-Chromosome Aberrations,
pubmed-meshheading:6786088-Chromosome Disorders,
pubmed-meshheading:6786088-Disease Models, Animal,
pubmed-meshheading:6786088-Epilepsy,
pubmed-meshheading:6786088-Female,
pubmed-meshheading:6786088-Genes, Dominant,
pubmed-meshheading:6786088-Genes, Recessive,
pubmed-meshheading:6786088-Humans,
pubmed-meshheading:6786088-Metabolism, Inborn Errors,
pubmed-meshheading:6786088-Neurofibromatosis 1,
pubmed-meshheading:6786088-Seizures, Febrile,
pubmed-meshheading:6786088-Spasms, Infantile,
pubmed-meshheading:6786088-Tuberous Sclerosis,
pubmed-meshheading:6786088-X Chromosome
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pubmed:year |
1981
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pubmed:articleTitle |
Genetic influences in the epilepsies. Review of the literature with practical implications.
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.,
Review,
Research Support, Non-U.S. Gov't
|