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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
1981-6-25
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pubmed:abstractText |
Persistent suppression of bacterial growth following exposure of both gram-positive and gram-negative bacteria to numerous antimicrobial agents was studied. The persistent, or postantibiotic, effect was quantitated by periodic counts of colony-forming units after removal of the drug by washing, dilution, or inactivation with penicillinase. Although a postantibiotic effect was observed with all drugs studied, there were marked differences among drugs in their postantibiotic effects on certain organisms. With gram-positive organisms, concentrations of beta-lactam antibiotics near the minimal inhibitory concentration produced persistent effects lasting 1-3 hr. With gram-negative organisms much higher concentrations were required to elicit a postantibiotic effect. Inhibitors of protein and RNA synthesis produced the longest persistent suppression of growth, which was of comparable duration in gram-positive and gram-negative bacteria. Only a short persistent effect of gentamicin was observed with Staphylococcus aureus and Escherichia coli, but a postantibiotic effect lasting 1.6-2.6 hr was observed with Pseudomonas aeruginosa. The duration of the postantibiotic effect was related linearly to concentration of drug and duration of exposure up to a point of maximal response. Persistent effects following exposure to antibiotics were also demonstrated in 90% human serum.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:issn |
0162-0886
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
3
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
28-37
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:6784225-Anti-Bacterial Agents,
pubmed-meshheading:6784225-Bacteria,
pubmed-meshheading:6784225-Biological Availability,
pubmed-meshheading:6784225-Dose-Response Relationship, Drug,
pubmed-meshheading:6784225-Erythromycin,
pubmed-meshheading:6784225-Escherichia coli,
pubmed-meshheading:6784225-Gentamicins,
pubmed-meshheading:6784225-Klebsiella pneumoniae,
pubmed-meshheading:6784225-Microbial Sensitivity Tests,
pubmed-meshheading:6784225-Penicillins,
pubmed-meshheading:6784225-Proteus mirabilis,
pubmed-meshheading:6784225-Pseudomonas aeruginosa,
pubmed-meshheading:6784225-Staphylococcus aureus,
pubmed-meshheading:6784225-Streptococcus pneumoniae,
pubmed-meshheading:6784225-Time Factors
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pubmed:articleTitle |
Postantibiotic suppression of bacterial growth.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
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