Linked Life Data

6782100

Source:http://linkedlifedata.com/resource/pubmed/id/6782100

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
1981-5-26
pubmed:abstractText
An IgG heteropolymer containing rheumatoid factor activity was isolated from the serum of a patient with the polyclonal hyperviscosity syndrome. This aggregating system was characterized using ultracentrifugation, classical light scattering, and rheological methods. The degree of polymerization is shown to be reversible and dependent on both pH and concentration. Light-scattering studies show a minimum stable intermediate consisting of four IgG monomers to exist at pH 7.4. The theoretical intrinsic viscosity and radius of gyration for the feasible configurations of such a tetramer were calculated. These models were compared to the experimental values. A cyclic structure is shown to be most compatible with the experimental data. Immunochemical analysis suggests that each tetramer contains two IgG1 rheumatoid factors binding to determinants on IgG3 Fc regions.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0021-9258
pubmed:author
pubmed:issnType
Print
pubmed:day
10
pubmed:volume
256
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
3240-4
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1981
pubmed:articleTitle
The physical characterization of an aggregating IgG heteropolymer containing rheumatoid factor.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't