Linked Life Data

6780924

Source:http://linkedlifedata.com/resource/pubmed/id/6780924

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1981-4-13
pubmed:abstractText
These studies utilized a prolactin-secreting clonal strain (2B8) of rat anterior pituitary cells. These cells secrete increasing amounts of prolactin in response to thyrotrophin releasing hormone (TRH) and do not produce any other pituitary hormone. In response to TRH and in the presence of calcium in the culture medium the cells demonstrated evoked responses without spike discharge following electrical stimulation. No spontaneous evoked response with spike discharge was observed in 2B8 cells. The evoked responses were not suppressed by tetrodotoxin (TTX) but were markedly suppressed by D-600, or lanthanum chloride. The results suggest that calcium ion flux across the cell membrane may be a necessary component of the intracellular events which lead to the release of prolactin.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0028-3835
pubmed:author
pubmed:issnType
Print
pubmed:volume
32
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
28-32
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1981
pubmed:articleTitle
Calcium-dependent changes in electrical properties of prolactin-secreting anterior pituitary (2B8) clonal cells.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.