Linked Life Data

6778610

Source:http://linkedlifedata.com/resource/pubmed/id/6778610

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1981-3-24
pubmed:abstractText
The prevalence, size, and patterns of distribution of arterial lesions (plaques) were investigated in cockerels exposed chronically to 7,12-dimethylbenz(a)anthracene (DMBA). Animals, from 5 to 20 weeks of age, received weekly i.m. injections of 5, 10, or 20 mg of DMBA per kg, dissolved in dimethyl sulfoxide. Control animals received weekly injections of dimethyl sulfoxide. All animals were sacrificed at 21 weeks of age. The entire aorta from each animal was cut transversely into 5-mm segments starting at the iliac trifurcation. The cross-sectional area of plaques was determined by light microscopic analysis of sections taken from the face of each segment. Plaque frequency was similar in DMBA-treated and control groups. However, mean plaque cross-sectional area was 7- to 11-fold higher for the treatment groups than for the controls. The distribution of plaque areas in both treated animals and controls was consistent with a log normal distribution. Median cross-sectional area and plaque volume index each increased in a linear fashion with DMBA dose. Small plaques were present in all groups. Large plaques were present only in DMBA-treated animals. Labeling indices of plaques, although low, were 2.3- to 26-fold higher than for underlying medial smooth muscle cells. The data indicate that the primary response to chronic DMBA exposure is a dose-dependent size increase of spontaneous aortic lesions and not the induction of new lesions.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0008-5472
pubmed:author
pubmed:issnType
Print
pubmed:volume
41
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
588-92
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1981
pubmed:articleTitle
Dose-dependent size increases of aortic lesions following chronic exposure to 7,12-dimethylbenz(a)anthracene.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.