Linked Life Data

6774642

Source:http://linkedlifedata.com/resource/pubmed/id/6774642

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1980-11-24
pubmed:abstractText
Six members of one family developed symptoms consistent with hypersensitivity pneumonitis after exposure to wood dust generated during the remodeling of a bathroom in their house. A detailed microbiologic investigation of the house and surrounding areas resulted in the isolation of 2-Bacillus species. The vegetative cell and spore extracts of these organisms were used for extensive in vivo and in vitro laboratory tests. All symtomatic members of the family demonstrated positive bronchoprovocation responses to vegetative cell extracts of B. subtilis. Two patients with clinical disease exhibited immediate positive skin tests to similar extracts. Positive lymphoproliferative responses to the vegetative cell extract of B. subtilis were observed in 4 of 5 symptomatic patients and in 1 additional patient tested with the spore form of B. subtilis. It is postulated that the abrupt appearance of this family epidemic depended on the special circumstance of continued exposure to high concentrations of B. subtilis organisms within the household. B. subtilis should be added to the list of antigens causing hypersensitivity penumonitis. Prompt recognition and elimination of this new causal agent could prevent irreversible lung damage in susceptible patients.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0003-0805
pubmed:author
pubmed:issnType
Print
pubmed:volume
122
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
339-48
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
1980
pubmed:articleTitle
Familial hypersensitivity pneumonitis induced by Bacillus subtilis.
pubmed:publicationType
Journal Article, Case Reports