Linked Life Data

6774488

Source:http://linkedlifedata.com/resource/pubmed/id/6774488

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1980-11-25
pubmed:abstractText
1. Inhalation exposure to xylene of technical grade (300 p.p.m. in air, 6 h a day, 5 days a week, up to 18 weeks) enhanced the overall mono-oxygenation reactions (7-ethoxycoumarin O-deethylase and 2,5-diphenyloxazole hydroxylase( as well as the UDP-glucuronyltransferase activity in rat liver microsomes. 2. The simultaneous ingestion of aqueous 15-20% ethanol as drinking fluid increased the cytochrome P-450 concn. and the mono-oxygenation activity even more than the xylene exposure alone. 3. Xylene-ethanol treatment resulted in additive or less than additive effects on the measured hepatic enzyme activities. 4. Renal ethoxycoumarin deethylase activity was enhanced both by ethanol ingestion and by xylene inhalation, and the response was additive after the combined exposure. 5. Liver histology revealed that even though the xylene exposure alone did not produce detectable liver damage, the xylene-ethanol treatment produced more severe liver damage than did ethanol ingestion alone.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0049-8254
pubmed:author
pubmed:issnType
Print
pubmed:volume
10
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
435-45
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1980
pubmed:articleTitle
The combined toxicity of technical grade xylene and ethanol in the rat.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, Non-P.H.S.