Linked Life Data

6774017

Source:http://linkedlifedata.com/resource/pubmed/id/6774017

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1980-11-20
pubmed:abstractText
The cellular origin of reticulum cell sarcoma (RCS) in SJL/J mice was studied by comparing the incidence of spontaneous RCS in control mice and in mice suppressed with goat anti-mu Ig from birth on. At 10 months of age anti-mu suppressed mice had 0% RCS as opposed to 60% in control mice. Growth of two i.v. injected transplantable RCS lines in anti-mu suppressed mice was approximately 60% as compared with growth in normal SJL/J mice. Proliferative responses of thymus and lymph node cells from anti-mu suppressed mice to RCS, mitomycin-treated syngeneic spleen cells (M. Spl.) Con A, and PHA were entirely normal. However, M. Spl. from anti-mu suppressed mice caused minimal or no stimulation of T cells from normal or anti-mu suppressed responders. The results suggest that the normal syngeneic stimulator cell is of B cell origin, either representing a direct precursor of RCS or indirectly influencing RCS appearance. A B cell origin of RCS is, furthermore, in agreement with some of its characteristics, such as surface markers (Ia antigens, Ly b) and in vivo localization properties.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0022-1767
pubmed:author
pubmed:issnType
Print
pubmed:volume
125
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1355-9
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
1980
pubmed:articleTitle
Suppression of spontaneous reticulum cell sarcoma development and of syngeneic stimulator cell by anti-mu treatment of SJL/J mice.
pubmed:publicationType
Journal Article