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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1980-10-24
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pubmed:abstractText |
We have investigated the relationship between pulmonary artery occlusion (PAO) and the surfactant system of the lung by studying the ultrastructural responses of type II alveolar pneumocytes to PAO of 4-12 h duration in 16 mongrel dogs. In six of these animals, the occluded lung was allowed to reperfuse for 6 h before killing and in four animals subjected to PAO of 4 h duration, the occluded lung was ventilated with 5% CO2 balance air. PAO by itself resulted in a dramatic 80% reduction in the volumetric density of lamellar bodies (LB) in the type II cells. This resulted predominantly from a decrese in volume of the individual LB. Although reperfusion was associated with an increase in LB volume density toward normal, 6 h of reperfusion was insufficient to re-establish normal type II cellular morphology. Ventilation of the occluded lung with 5% CO2 prevented LB depletion indicating that alveolar CO2 tension may affect the release and/or synthesis of LB in type II pneumocytes.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/6772668-1093459,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6772668-13164334,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6772668-13649082,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6772668-13750428,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6772668-13774279,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6772668-14173422,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6772668-14223920,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6772668-14902247,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6772668-15406250,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6772668-16977,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6772668-1706,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6772668-4110304,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6772668-4294347,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6772668-4678089,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6772668-4698262,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6772668-5109934,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6772668-5178794,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6772668-5205189,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6772668-5804130,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6772668-5810820,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6772668-5935208,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6772668-5944934,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6772668-6025736,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6772668-6025737,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6772668-6025758
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0021-9738
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
66
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
36-42
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:6772668-Animals,
pubmed-meshheading:6772668-Arterial Occlusive Diseases,
pubmed-meshheading:6772668-Carbon Dioxide,
pubmed-meshheading:6772668-Dogs,
pubmed-meshheading:6772668-Lung Compliance,
pubmed-meshheading:6772668-Microscopy, Electron,
pubmed-meshheading:6772668-Pulmonary Alveoli,
pubmed-meshheading:6772668-Pulmonary Artery,
pubmed-meshheading:6772668-Pulmonary Surfactants,
pubmed-meshheading:6772668-Respiration
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pubmed:year |
1980
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pubmed:articleTitle |
Lamellar body depletion in dogs undergoing pulmonary artery occlusion.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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