Linked Life Data

6771489

Source:http://linkedlifedata.com/resource/pubmed/id/6771489

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1980-9-28
pubmed:abstractText
The status of de novo pyrimidine synthesis in the dp mutant of Drosophila melanogaster was examined by measuring the activity of the rate-limiting orotate phosphribosyl transferase (OPRT) enzyme. Activity is significantly elevated in late third instar larvae of 5 different dp mutant strains. A more detailed analysis of a dpovc allele has shown that this elevation arises at about mid-larval life and persists until pupation. A low nucleotide diet causes a depression in OPRT activity in dpovc larvae which can be reversed by dietary supplementation of uracil. However, neither the low nucleotide diet nor uracil supplementation results in a change in the expressivity of the dp mutant phenotypes. Changes in expressivity are produced by 6-azauracil and by elevated temperature although, in those cases, the effect on OPRT activity is minimal. The significance of the observations is discussed in relation to the role of pyrimidine biosynthesis in dp expressivity and chitin synthesis.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0026-8925
pubmed:author
pubmed:issnType
Print
pubmed:volume
178
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
437-42
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1980
pubmed:articleTitle
Pyrimidine biosynthesis in the dumpy mutants of Drosophila melanogaster.
pubmed:publicationType
Journal Article