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rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
5
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|
pubmed:dateCreated |
1980-8-15
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|
pubmed:abstractText |
A series of 2,4-disubstituted 8-aminoquinoline analogues were synthesized and evaluated against Plasmodium berghei in mice and Leishmania donovani in hamsters. 8-[[6-(Diethylamino)hexyl]amino]-2-ethyl-6-methoxy-4-methylquinoline (8a) possessed significant activity against L. donovani. 2-Ethyl-4-methylprimaquine (7a) was evaluated against Plasmodium cynomolgi in rhesus monkey and found to have activity equal to that of primaquine.
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pubmed:language |
eng
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|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0022-2623
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|
pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:volume |
23
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pubmed:owner |
NLM
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|
pubmed:authorsComplete |
Y
|
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pubmed:pagination |
581-4
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:6770089-Aminoquinolines,
pubmed-meshheading:6770089-Animals,
pubmed-meshheading:6770089-Antimalarials,
pubmed-meshheading:6770089-Antiprotozoal Agents,
pubmed-meshheading:6770089-Chemical Phenomena,
pubmed-meshheading:6770089-Chemistry,
pubmed-meshheading:6770089-Haplorhini,
pubmed-meshheading:6770089-Leishmania,
pubmed-meshheading:6770089-Macaca mulatta,
pubmed-meshheading:6770089-Malaria,
pubmed-meshheading:6770089-Plasmodium
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pubmed:year |
1980
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|
pubmed:articleTitle |
Synthesis of 2,4-disubstituted 6-methoxy-8-aminoquinoline analogues as potential antiparasitics.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.
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