Linked Life Data

6767829

Source:http://linkedlifedata.com/resource/pubmed/id/6767829

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1980-6-25
pubmed:abstractText
In vitro antisheep erythrocyte (SRBC) and antitrinitrophenyl (TNP) antibody responses of spleen cells obtained from C57BL/6 mice infected with Trypanosoma cruzi were reduced as early as 6 days postinfection and not detectable after 18 days of infection. Lymph node cells had normal antibody responses to SRBC and TNP in vitro until the 11th day of infection, after which responses were diminished. By day 31 of infection, lymph node cells were unresponsive to both SRBC and TNP in vitro. Not only were the antibody responses of spleen and lympho node cells to T-cell-dependent and -independent antigens progressively reduced as the period of infection increased, but in addition, the effect of lymphoid cell density and antigen dose on antibody production underwent several sequential changes. As the infection advanced, low densities of cultured lymphoid cells and low doses of antigen were ineffective in eliciting a detectable immune response, whereas high densities of lymphoid cells and high doses of antigen resulted in responses approximately equivalent to that observed with normal cells under the same conditions. Results of cell mixing studies have shown that a plastic-adherent, macrophage-like cell plays a major role in the suppressed humoral responses observed in this host-parasite system.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0022-3395
pubmed:author
pubmed:issnType
Print
pubmed:volume
66
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
16-27
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1980
pubmed:articleTitle
Trypanosoma cruzi-induced suppression of the primary immune response in murine cell cultures to T-cell-dependent and -independent antigens.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.